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KMID : 0369820100400060347
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Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 6 p.347 ~ p.351
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Determination of Physicochemical Properties and Pharmacokinetic Profiles of Soybean Extracts
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Jung Hyun-Chan
You Sung-Kyun
Kwon Sun-Kyu
Hwang Ji-Sook
Cho Cheong-Weon
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Abstract
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Isoflavones have received much attention because of their health-related and clinical benefits such as estrogenic and anti-oxidative activities as well as triggering of natural killer cell activity. However, there are few publications reporting the pharmacokinetic profiles together with physicochemical properties of main isoflavones. Therefore, the pharmacokinetic parameters of main aglycones, daidzein, glycitein and genistein after oral administration of soybean extracts were investigated and the physicochemical properties of soybean extracts were characterized. It was observed that angle of repose was 46o and tap density, bulk density and porosity were 10.12, 4.3 and 0.86 g/cm3 and the mean AUClast of daidzein, glycitein and genistein was 11.376 μg·h/mL, 3.045 μg·h/mL and 0.825 μg·h/mL, respectively. Cell viability was
60% at a concentration of 10 mg/mL. Taken together, it was suggested that isoflavones were contained in the soybean
products and had an antioxidant activity and this study would be the basis to control the quality of soybean products and
study of the bioequivalence between soybean products in future.
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KEYWORD
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Isoflavones, Soybean extracts, Pharmacokinetic, Physicochemical, Cell viability, Solubility
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